Abstract: Research on the biosecurity research themes and evolution trends of relevant American think tanks since the 21st century, so as to provide reference for promoting the construction of China’s biosecurity think tanks and security discourse system and improving China’s biosecurity protection and governance system. Based on the LDA-Word2vec model, taking the research outputs of six mainstream think tanks in the fields of national defense and security in the United States as samples, and using the tenure of each U.S. president as the criterion for phase division, this paper analyzes the theme identification and evolution and finds that on the basis of forming the thematic framework, the evolution process of biosecurity research by American think tanks can be divided into three evolutionary stages: theme rise and system construction, strategic development and practice deepening, technological innovation and international cooperation. Additionally, it identifies eight key paths, including public health, biological surveillance and defense. Therefore, China should strengthen the construction of domestic biosecurity think tanks and contribute Chinese wisdom; promote the forward movement of biosecurity risk prevention and control and strengthen the integration of science and technology; actively participate in international biosecurity governance and enhance its international voice; pay attention to emerging development areas of biotechnology and deepen interdisciplinary exchanges.

Key words: Biosafety; American Think Tank; LDA Model; Word2vec; Theme Evolution; Biological Surveillance and Defense