世界科技研究与发展 ›› 2025, Vol. 47 ›› Issue (3): 361-371.doi: 10.16507/j.issn.1006-6055.2024.12.001 cstr: 32308.14.1006-6055.2024.12.001

• 科技管理与政策 • 上一篇    

美英澳合成生物学评估实践及启示

马雪晴1,2 朱成姝1 张学博1 刘晓1 陈大明1,2 熊燕1,2   

  1. 1.中国科学院上海生命科学信息中心,中国科学院上海营养与健康研究所;2.中国科学院大学
  • 发布日期:2025-06-04
  • 基金资助:
    国家重点研发计划”合成生物学生物安全”(2020YFA0908601)

Practice and Inspiration of Synthetic Biology Assessments in the United States, the United Kingdom and Australia

MA Xueqing1,2 ZHU Chengshu1 ZHANG Xuebo1 LIU Xiao1 CHEN Daming1,2 XIONG Yan1,2   

  1. 1.Shanghai Information Center for Life Sciences, Shanghai Institute of Nutrition and Health,Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences; 2.University of Chinese Academy of Sciences
  • Published:2025-06-04

摘要: 合成生物学正以颠覆性态势推动生物技术创新,赋能医药、农业及环保等领域发展。美、英、澳等国已强化战略布局,通过路线图制定与系统评估推进该领域发展。本文系统梳理了美英澳三国对合成生物学/工程生物学进展的评估及远景展望。研究发现,三个国家依据各自发展目标开展了独具特色的评估,基本遵循”目标—结果—举措”的评估框架,重点构建了创新水平、产业发展及基础生态环境三大模块的核心评估指标,并主要以定性的描述性分析,辅以定量分析的方法对合成生物学的进展进行回顾及评估。同时,本文通过对我国合成生物学领域评估的实践探索总结,从评估策略、评估框架、评估方法三方面对我国评估提出相关建议,为我国构建更为精准高效、适应性强的评估体系,开展合成生物学等新兴技术领域的评估提供借鉴与参考。

关键词: 合成生物学;进展评估;新兴技术;评估体系

Abstract: Synthetic biology is driving biotechnology innovation in a disruptive manner, empowering the development of medicine, agriculture, and environmental protection. The United States (U.S.), the United Kingdom (U.K.), Australia and other countries have strengthened their strategic layout and promoted the development of this field through roadmap formulation and systematic assessment. In this paper, we systematically reviewed the assessment and outlook of the progress of synthetic/engineering biology in the U.S., U.K. and Australia. It was found that the three countries had carried out unique assessments based on their respective development goals, basically following the assessment framework of “goals-results-initiatives”, focusing on the construction of core assessment indicators of the three modules of innovation level, industrial development and basic ecological environment, and mainly using qualitative and descriptive analysis, supplemented by quantitative analysis to review and assess the progress of synthetic biology. At the same time, this paper summarized the practice of assessment of synthetic biology in China, and put forward relevant suggestions on the assessment from the aspects of assessment strategy, assessment framework and assessment method, so as to provide reference for China to build a more accurate, efficient and adaptable assessment system, and to carry out the assessment of synthetic biology and other emerging technology fields.

Key words: Synthetic Biology; Progress Assessment; Emerging Technologies; Assessment System