Abstract: The construction of the Guangdong-Hong Kong-Macao Greater Bay Area as an international hub for technological innovation urgently requires an efficient, collaborative, and open science and technology service system as support. However, the regional science and technology service industry currently faces six major structural bottlenecks, including a mismatch between industrial scale and economic status, regional development imbalances, structural shortages of high-end talent, insufficient marketization, lagging institutional standards, and a polarization of service capabilities. These issues severely constrain the unleashing of innovation potential.As a strategically planned international hub for technological innovation at the national level,the Greater Bay Area is positioned at a critical historical juncture where China’s technological innovation is transitioning from “catching up” and “running alongside” to “leading the way.” In this context, how to proactively plan and establish the “core hub for the eastward shift of international scientific centers” has become the central focus of this paper. Simultaneously, addressing the aforementioned six structural bottlenecks is identified as the core task. Through methods such as case analysis and comparative study, this paper systematically draws on advanced experiences from developed economies in organizing science and technology service industries. Ultimately, it proposes six strategic measures: promoting industrial upgrading through dual drivers of scale expansion and capacity enhancement; fostering regional coordination by balancing gradient layout and resource sharing; advancing talent development with equal emphasis on cultivation, introduction, and evaluation; stimulating market vitality through deepened reforms and tailored cultivation; improving institutional innovation by harmonizing standard unification and regulatory optimization; and promoting balanced development through capability enhancement and resource integration.

Key words: Guangdong-Hong Kong-Macao Greater Bay Area; Science and Technology Services; Development Bottlenecks; Pathways Research