Under the background of China-US trade embargo, a series of external technical threats are increasingly prominent in China, which affects a variety of fields such as economics, military, politics etc. Developed countries, led by the United States, restrict the export of key core technologies to China through Export Control. The commerce control list (CCL) issued by the United States contains export restrictions on a large number of technologies, equipment and products, including important scientific instruments and their related parts. This paper compares the contents of the CCL with the classification of domestic scientific instruments, taking the commercial control list as object text, and taking the classification of scientific instruments in China as standards. Through text mining and clustering, the analysis of the technology of export control list is carried out. Then, the distribution of the control situation of the United States in each type of scientific instrument and technology is analyzed. It is found that 42.08% of the list items are related to the control of scientific instruments, suggesting serious situation for the field of scientific instruments in China. Among the 12 categories of scientific instruments, Analytical Instruments, Process Experimental Equipments, Electronic Measuring Instruments, etc. are subject to a wide range of control. Medical Diagnostic Instruments, Atmospheric Detection Instruments are controlled slightly. On the basis of the analysis, this paper puts forward some suggestions for the development of scientific instruments in China.