世界科技研究与发展 ›› 2022, Vol. 44 ›› Issue (3): 354-370.doi: 10.16507/j.issn.1006-6055.2022.05.007

• 科研仪器与设施专题刊 • 上一篇    下一篇

国产质子转移反应质谱仪的发展现状

邹雪 张强领 梁渠 陆燕 夏磊 刘亚伟 黄超群 沈成银 储焰南   

  1. 中国科学院合肥物质科学研究院健康与医学技术研究所,医学物理与技术安徽省重点实验室,合肥230031
  • 出版日期:2022-06-25 发布日期:2022-07-04
  • 基金资助:
    国家自然科学基金“车载质谱仪反应管内静电场软聚焦的离子高效引导方法研究”(22076190),中国科学院合肥物质科学研究院院长基金“基于离子漏斗-多源光电离/化学电离质谱的呼气VOCs双模检测新方法研究”“高灵敏闻诊谱仪研发及示范应用”(YZJJ2022QN45,YZJJZX202009),中国科学院青年创新促进会人才项目(2019432)

Current Development of Domestic Proton Transfer Reaction Mass Spectrometry

ZOU Xue   ZHANG Qiangling   LIANG Qu   LU Yan   XIA Lei   LIU Yawei   HUANG Chaoqun SHEN Chengyin   CHU Yannan   

  1. Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China
  • Online:2022-06-25 Published:2022-07-04

摘要:

质子转移反应质谱(Proton Transfer Reaction Mass Spectrometer,PTR-MS)是一种快速高灵敏的挥发性有机物检测技术。国产PTR-MS自2008年建成以来,已经在部分技术和应用领域达到国际先进水平。本文首先介绍了仪器原理,阐明了待测物离子化、传输、探测过程中的主要影响因素。然后展示了国产PTR-MS的产品线,主要包括质子反转移反应质谱仪、双极性质子转移反应质谱仪、呼气检测仪、船载液体进样质谱仪、车载大气走航监测质谱仪、快速色谱质子转移反应质谱仪等,部分产品已经实现了批量生产和销售。技术发展方面,在灵敏度提升和多反应离子制备上取得了重要进展。最后介绍了国产PTR-MS在环境、医学、安全等领域的应用,比如大气污染溯源、人体呼气中疾病标志物的发掘、爆炸物快检等。同时,展望了国产PTR-MS的发展方向和应用前景。

关键词: 国产, 质子转移反应质谱仪, 产品, 应用

Abstract:

Proton transfer reaction mass spectrometry (PTR-MS) is a rapid and sensitive technique for the detection of volatile organic compounds. Since its completion in 2008, domestic PTR-MS has reached the international advanced level in some technology and application fields. In this paper, we firstly introduced the principle of the instrument, and expounded the main influencing factors in the process of ionization, transmission and detection of the object to be measured. Then we showed the main products of domestic PTR-MS, including proton extraction reaction mass spectrometer (PER-MS), dipolar proton transfer reaction mass spectrometer (DP-PTR-MS), breath tester, spray inlet mass spectrometer (SI-PTR-MS), mobile proton transfer reaction mass spectrometer (M-PTR-MS), fast gas chromatography proton transfer reaction mass spectrometer (FGC-PTR-MS). Some products have been mass produced and sold. In terms of technological development, important progress has been made in the improvement of sensitivity and the preparation of multi reactive ions. Finally, we introduced the application of domestic PTR-MS in the fields of environment, medicine and safety, such as tracing the source of air pollution, excavating disease markers in human exhalation, rapid detection of explosives and soon. At the same time, the future development direction and application prospect of domestic PTR-MS were prospected.

Key words: Domestic, Proton Transfer Reaction Mass Spectrometer, Products, Application